About PAG LABS — Evidence-First Skin Longevity

PAG LABS is a skin-longevity supplement brand built around a simple rule: separate what is established in humans from what is promising in laboratory and early clinical research.

Skin aging is influenced by ultraviolet exposure, genetics, smoking, nutrition, sleep, metabolic health, inflammation, extracellular-matrix remodeling and normal changes in cellular function. No single capsule, cream or pathway explains all of it. Our goal is to make this biology easier to understand without turning emerging science into certainty.

What “evidence-first” means at PAG LABS

Our Research Library uses four evidence levels:

• Human clinical evidence: randomized or controlled studies measuring outcomes in people.
• Human biomarker evidence: studies showing a biological change in people without proving a visible or clinical skin outcome.
• Mechanistic evidence: research explaining a pathway in cells, tissues or biochemical systems.
• Preclinical evidence: laboratory or animal research that may justify further study but cannot by itself establish a human benefit.

We do not treat these categories as interchangeable. A compound can have an interesting mechanism and still lack evidence that taking it changes wrinkles, elasticity or other visible skin outcomes.

Our focus: skin longevity

We use skin longevity to describe maintaining skin function and resilience over time. That includes established topics such as photoprotection and retinoids, as well as active research areas including NAD+ biology, cellular senescence, matrix metalloproteinases, polyphenols and nutritional interventions.

Where strong human evidence exists, we say so. Where evidence is mixed, indirect or preliminary, we say that too.

Formula transparency

PAG NAD CORE™ uses a fully disclosed formula with no proprietary blend. Per 2-capsule serving, the Supplement Facts panel lists:

• NAD+ (Nicotinamide Adenine Dinucleotide): 500 mg
• Quercetin Dihydrate Extract: 250 mg (Sophora japonica, whole flower bud)
• Japanese Knotweed Extract: 150 mg, standardized to 98% resveratrol (Polygonum cuspidatum, root)

One bottle contains 60 capsules / 30 servings. The PAG NAD CORE 90-day protocol consists of 3 bottles.

A critical distinction: NAD+ is not NR or NMN

PAG NAD CORE contains NAD+ itself. It does not contain nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN). Human trials showing that NR or NMN raises NAD-related biomarkers are relevant to the broader field of NAD biology, but they are not direct evidence that an oral NAD+ product produces the same pharmacokinetics or outcomes. Our editorial standard is to preserve that distinction.

Our editorial principles

• Prefer primary research and systematic reviews over marketing claims.
• Name the population, intervention and outcome when a study is discussed.
• Distinguish association from causation.
• Do not extrapolate a precursor study to direct NAD+ without saying so.
• Do not present animal or cell findings as proven human effects.
• Correct content when the underlying evidence or our product information changes.

Commercial disclosure

PAG LABS sells PAG NAD CORE. That creates a commercial interest in topics related to NAD+, quercetin and resveratrol. Readers should consider that relationship when evaluating our interpretation of the evidence. Our aim is to make the distinction between evidence and product context explicit rather than hide it.

Last reviewed: September 2026.

Educational content is not medical advice. Dietary supplements are not intended to diagnose, treat, cure or prevent disease.