PAG Labs Research Briefing
The science behind structural skin aging.
Facial aging is not only a surface problem. PAG Labs frames dermal aging as a systems-level failure involving NAD+ decline, sirtuin suppression, senescent fibroblast accumulation, and collagen glycation.
The protocol targets collagen loss upstream, before visible surface change becomes permanent.
The biology
Three failure modes converge inside the dermis.
After midlife, NAD+ availability declines, sirtuin activity drops, and MMP-1 collagenase becomes harder to suppress. At the same time, senescent fibroblasts secrete inflammatory SASP signals, while glycation stiffens collagen and elastin fibers.
01
NAD+ depletion
NAD+ is required for sirtuin signaling, mitochondrial repair, inflammatory control, and collagenase regulation.
02
Senescent fibroblasts
Damaged fibroblasts remain metabolically active and release SASP signals that accelerate matrix breakdown.
03
AGE cross-linking
Advanced glycation end-products make collagen rigid and difficult to remodel, even when new collagen is produced.