PAG Labs Research Briefing
NAD+ anti-aging starts beneath the surface.
NAD+ is the cofactor behind sirtuin signaling, mitochondrial repair, inflammatory control, and collagenase regulation. PAG NAD CORE(TM) uses NAD+ as the first step in a three-part dermal remodeling protocol.
The protocol targets collagen loss upstream, before the surface changes become visible.
Why NAD+ matters
Aging skin is an energy and signaling problem.
NAD+ supports the enzymes that maintain cellular repair, mitochondrial output, and inflammatory regulation. In dermal tissue, those signals influence how fibroblasts behave and how aggressively collagen-degrading enzymes such as MMP-1 are expressed.
When NAD+ availability drops, sirtuin activity falls with it. The result is a weaker repair environment: higher oxidative stress, lower fibroblast performance, more inflammatory signaling, and less control over collagenase pressure.
The four NAD+ effects
NAD+ is the upstream cofactor, not the whole protocol.
01
Sirtuin activation
SIRT1 and SIRT3 depend on NAD+ to regulate stress response, inflammatory transcription, and collagenase activity.
02
Fibroblast energy
Collagen synthesis is energy-intensive. NAD+ helps restore the mitochondrial environment that fibroblasts need to rebuild matrix.
03
MMP-1 suppression
With sirtuin signaling restored, the pathway that restrains MMP-1 collagenase becomes biologically accessible again.
04
Repair readiness
NAD+ prepares the cellular environment, but senescent-cell cleanup and glycation control are still needed for a complete cycle.
Why combination matters
NAD+ alone recharges the pathway. It does not clear every obstacle.
Use NAD+ as the foundation, then complete the cycle.
PAG NAD CORE(TM) combines NAD+, Quercetin, and Resveratrol in a complete 90-day protocol designed around dermal matrix biology.
View the Protocol