Clinical Formulation
HPLC-verified · 60 caps/bottle · 3-bottle protocol
PAG NAD CORE™
It was never the creams. What changes with age is cellular, and it happens below the layer a cream can reach.
Your skin blocks most molecules larger than 500 Daltons. Collagen is around 300,000. That is why creams sit on the surface and change nothing underneath. This works from the inside, targeting three cellular processes tied to how skin ages. Two capsules a day. Ninety days. That is the whole protocol.
If you’ve tried creams, serums, and treatments without lasting results — it’s not that they don’t work on you. They can’t work on anyone. Your skin blocks most molecules over 500 Daltons at the surface. Collagen is around 300,000. The only way to change what’s actually happening is to work from the inside, targeting the three cellular failures driving visible aging at the same time.
Baby skin biology
The East Asian skin advantage is biochemical, not cosmetic.
The baby skin look associated with many East Asian aging patterns is not a cream effect. It reflects a deeper cellular state: lower collagenase pressure, better matrix preservation, reduced glycation burden, and stronger sirtuin signaling.
PAG NAD CORE™ recreates those conditions from within: NAD+ for sirtuin signaling, Quercetin for senescent-cell clearance, and Resveratrol for glycation control during the rebuilding window.
Creams stop at the surface
A moisturizer can improve glow. It cannot rebuild the dermal environment.
The 500 Dalton Rule
Creams are limited by physics
The stratum corneum blocks most molecules above ~500 Daltons. Collagen is around 300,000 Da. Most serums exceed 1,000 Da. The great majority of topical actives never reach the dermis, where structural aging happens.
MMP-1 Collagenase
The real culprit is enzymatic
MMP-1 collagenase cuts through collagen fibers like molecular scissors — triggered by UV, stress, and sugar. No cream deactivates this pathway. It needs systemic support.
Cellular Energy Crisis
NAD+ depletion drives aging
NAD+ levels drop roughly 50% between age 20 and 60. Without it, sirtuin signaling collapses, cellular repair slows, and the dermal matrix can’t maintain its architecture.
Complete formulation
Three compounds. Three failure modes. One protocol.
Supplement Facts
Serving size: 2 capsules · Servings per container: 30Other ingredients: HPMC vegetable capsule, Microcrystalline Cellulose, Brown Rice Flour, Olive Oil, Silicon Dioxide, Magnesium Stearate (vegetable source). Free from: heavy metals · GMO · artificial binders · gluten.
“Baby skin is not a surface finish. It is a cellular state: low collagenase pressure, clean fibroblast signaling, and collagen that can stay flexible.”
The molecular stack
How each compound translates the Asian skin-longevity pattern.
NAD+
The central cofactor for cellular energy metabolism and sirtuin activity. NAD+ levels drop roughly 50% between age 20 and 60. Restoring them supports SIRT1/SIRT3 signaling — which regulates stress response, inflammatory transcription, and MMP-1 collagenase pressure on the dermal matrix. Delivered as Nicotinamide Riboside (NR), a precursor with high oral bioavailability.
Quercetin
A senolytic polyphenol that supports clearance of senescent fibroblasts. These damaged cells release SASP — the inflammatory secretome that accelerates collagen breakdown. Quercetin reduces the burden that ages skin from the inside out.
Resveratrol
A SIRT1-activating polyphenol with direct glycation-control relevance. Glycation — the cross-linking of collagen fibers by sugar — stiffens and degrades the matrix as it forms. Resveratrol helps protect the quality of newly synthesized collagen during the 90-day rebuilding window.
The protocol structure
Why 90 days — and what happens inside them.
Skin does not renew in a week. The biological processes targeted here operate on a timeline of months. The 90-day structure matches that reality — it isn’t a marketing round number.
3 bottles. 90 days. One structured protocol designed to matter.
Arrest
NAD+ restoration supports SIRT1/SIRT3 signaling and begins reducing MMP-1 collagenase pressure. Senescent fibroblast clearance starts. The cellular environment stabilizes. Nothing visible yet — and that is expected.
Rebuild
Healthy fibroblasts restart Type I and III collagen output. Texture and elasticity changes begin to appear.
Integrate
New collagen matures into stable architecture. Resveratrol protects it from glycation. The compounding effect of three months becomes visible.
Everything the complete cycle requires
Sold as a full 90-day allocation because collagen breakdown, fibroblast output, and matrix integration do not complete inside a 30-day cosmetic window.
Customer reviews
Verified reviews from customers who completed the full 90-day protocol will appear here.
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Frequently asked
Your questions, answered.
It’s a fair question. The supplement industry is full of underdosed formulas and ingredients chosen for marketing rather than biology. Your skepticism is earned. What distinguishes PAG NAD CORE™: every ingredient is dosed at amounts used in peer-reviewed research rather than trace amounts for label decoration, purity is HPLC-verified at ≥98% per batch, and the formulation addresses three distinct pathways at once. We can’t guarantee results for everyone — no honest brand can. We can guarantee that if you complete the full 90 days and see no visible difference, we refund the entire purchase.
Most people begin noticing changes in skin texture and how rested their face looks during Phase 2 (days 31–60). The most meaningful structural changes appear by the end of the full 90-day cycle. Collagen biology runs on weeks-to-months timelines; this protocol is calibrated to match it. Individual results vary.
Yes. PAG NAD CORE™ works internally and does not interfere with topical routines. Improving the internal cellular environment can make topical products perform better — healthier skin cells respond more effectively to hydration and surface treatments.
No. The pathways targeted — NAD+/SIRT1 signaling, senescent cell clearance, collagen matrix maintenance — are universal. The formulation is designed for any adult experiencing the biological effects of age on skin quality.
Most NAD+ supplements are positioned for energy or general longevity. PAG NAD CORE™ is formulated specifically as a dermal protocol — pairing NAD+ (as highly bioavailable Nicotinamide Riboside) with a senolytic (Quercetin) and a SIRT1 activator (Resveratrol) at clinically relevant doses, targeting three failure modes at once.
NAD+ (NR), Quercetin, and Resveratrol are generally well-tolerated at these doses. Quercetin can occasionally cause mild digestive sensitivity when taken without food — taking it with a meal avoids this. Consult your healthcare professional if you are pregnant, nursing, taking anticoagulants or immunosuppressants, or have a medical condition.
No. No subscription, no auto-billing, no surprise charges. One purchase, one complete protocol. You decide whether to continue after day 90.
Complete the full 90-day protocol as directed. If you do not observe visible improvement in your skin’s texture, firmness, or overall quality, contact us for a full refund. We ask only that you give the protocol its full duration — results require consistency, not occasional use.
Before you decide
Still not sure?
Good. You should be skeptical.
The PAG Labs Guarantee
You’re not buying a supplement.
You’re running a 90-day test — at our risk, not yours.
Complete the protocol. Two capsules, every morning, for 90 days straight. If your skin doesn’t look visibly different — in texture, firmness, or the way you look in photos — you email us and we refund every cent.
Why can we make this guarantee? Because the formulation isn’t a guess. 500 mg NAD+ (as NR) to restore sirtuin signaling and reduce MMP-1 collagenase pressure. 250 mg Quercetin to clear senescent fibroblasts and the SASP inflammation they leak. 150 mg Resveratrol to block glycation of the collagen you rebuild. Three failure modes, addressed at once, for the full 90 days collagen actually needs.
What people ask before ordering
I see nothing at day 30. Normal?
Completely normal, and expected. Days 1–30 are the arrest phase: NAD+ is suppressing MMP-1 collagenase, Quercetin is beginning senolytic clearance. The visible change happens at day 60–90, when newly synthesized collagen fibers mature. Any product promising visible change in 7 days is describing hydration, not structure.
What if I complete it and see nothing?
You get your money back. No debate, no conditions, no exceptions. Email us at the end of the 90 days and the refund is processed the same week.
Is this a subscription? Auto-billing?
No subscription. No auto-billing. No surprise charges. One purchase, one complete protocol. You decide if you want to continue after day 90.
I’m already using a cream. Can I combine?
Yes. PAG NAD CORE™ works systemically, from within. It doesn’t interfere with topical products. If you use retinol or SPF — keep using them. Inside-out and outside-in are complementary, not competing.
What happens after the 90 days?
NAD+ depletion and senescent cell accumulation are ongoing biological processes, so the cellular pressure returns over time. Many customers continue with one bottle a month as maintenance. That is optional, never automatic, and never billed without you asking.
90-day guarantee · free shipping · no subscription
Your skin is already programmed to stay young.
It just needs the right cellular environment. That’s all this is.
3 bottles · complete 90-day protocol · full refund if no visible result.